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ModRev is a command line tool to revise Boolean logical models of biological regulatory networks.
This tool was developed for UNIX and MacOSX systems.
ModRev is able to repair inconsistent Boolean models under the following:
- Set of stable state observations
- Set of time-series observations
- With synchronous update scheme
- With asynchronous update scheme
Releases
- ModRev v1.3.1
- ModRev v1.2.3 (only supports either stable state or time-series observations but not both simultaneously)
- ModRev v1.1.0 (only supports stable state observations)
Additional material
- Examples of inconsistent networks: inputNetworks
- Examples of time-series observations: observations
Validation
Check here for more information about experimental validation.
Publications
-
F. Gouveia, I. Lynce, P.T. Monteiro (2020)
ModRev - Model Revision Tool for Boolean Logical Models of Biological Regulatory Networks
in A. Abate, T. Petrov, V. Wolf (editors)
Computational Methods in Systems Biology (CMSB 2020), LNCS 12314, 339-348, Springer
doi:10.1007/978-3-030-60327-4_18 -
F. Gouveia, I. Lynce, P.T. Monteiro (2020)
Revision of Boolean models of regulatory networks using stable state observations
Journal of Computational Biology, 27(2): 144-155
doi:10.1089/cmb.2019.0289 -
F. Gouveia, I. Lynce, P.T. Monteiro (2019)
Model revision of Boolean regulatory networks at stable state
in Z. Cai et al. (editors)
Proc. of the 15th International Symposium on Bioinformatics Research and Applications (ISBRA’19), LNCS 11490, 1-13
doi:10.1007/978-3-030-20242-2_9
Authors
- Filipe Gouveia
- Inês Lynce
- Pedro Monteiro
Contact
If you have any comments or questions, please contact us.